A Pharmacokinetics and Safety Study of Naproxcinod in Subjects With Impaired Renal Function

Exclusion Criteria

• •Any significant acute or chronic disease (except renal impairment) which may interfere with study evaluations.
• •A history of alcohol or drug abuse.
• •Diagnosis of gastric or duodenal ulceration and/or history of significant gastro-duodenal bleeding within the last 6 months
• •Clinically relevant abnormal ECG
• •Current or expected use of anticoagulants or analgesic, anti-inflammatory therapies except low dose aspirin (less than or equal to 325mg per day).
• •Participation within 30 days prior to screening in another investigational study.