prior radiation, chemotherapy, hormontherapy and immunotherapy

patients with more than 3 afflicted lymph nodes

afflicted lymph nodes on the cantralateal side and/or afflicted supraclavicular or intraclavicular lymph nodes

bilateral breast cancer or second carcinoma of the breast

inflammatory breast cancer and/or distant metastases

existing clinically relevant peripheral neuropathie

heart infection during the last 6 months or therapeutically not compensated heart failure or cardiac arrhythmias of at least LOWN II

patients with active infections and/or not controlled hypercalcemia

pregnant or breastfeeding women or women of child-bearing age who do not use effictive contrazeptiva

Adjuvant Treatment of Breast Cancer With 1-3 Aflicted Lymph Nodes