Lead Sponsor

North Eastern German Society of Gynaecological Oncology

Age

18 - 75 years

Sex

FEMALE

Healthy Volunteers

No

•women with histologically proven breast cancer (pT1/pT2/pT3, pN1, N0)
•ECOG performance status 0-1
•start of adjuvant therapy not later than 4 weeks after surgery
•hematology: platelets at least 100xGpt/l, neutrophiles at least 2xGpt/l
•normal liver function as defined by: bilirubine till 1.5 x normal value, SGOT/SGPT till 1.25 x normal value
•normal kidney function as defined by: creatine till 1.5 x normal value
•negative pregnancy test for patients before menopause and effective contraception
•written informed consent

•prior radiation, chemotherapy, hormontherapy and immunotherapy
•patients with more than 3 afflicted lymph nodes
•afflicted lymph nodes on the cantralateal side and/or afflicted supraclavicular or intraclavicular lymph nodes
•bilateral breast cancer or second carcinoma of the breast
•inflammatory breast cancer and/or distant metastases
•existing clinically relevant peripheral neuropathie
•heart infection during the last 6 months or therapeutically not compensated heart failure or cardiac arrhythmias of at least LOWN II
•patients with active infections and/or not controlled hypercalcemia
•pregnant or breastfeeding women or women of child-bearing age who do not use effictive contrazeptiva