A Phase 1 Study of AIR645 in Healthy Subjects and Subjects With Controlled Asthma

Exclusion Criteria

• •Clinically significant medical history or condition which precludes participation
• •Clinically significant ECG abnormality
• •Clinically significant VS or PE abnormality
• •Clinically significant screening lab abnormality
• •Abnormal lung function (FEV1 \<80% predicted)
• •Respiratory infection within 14 days of randomization
• •HBV, HCV, or HIV
• •Breastfeeding or pregnant female
• •History of alcohol abuse or illicit drug use within past 24 months
• •Use of any tobacco or nicotine-containing product within past 6 months
• •Use of any herbal supplement, over-the-counter drug, or prescription drug that is not allowed per protocol
• •Use of any investigational drug within past 30 days
• •Use of any investigational monoclonal antibody or recombinant protein within past 90 days
• •Donation of plasma within past 7 days
• •Donation or loss of whole blood within past 56 days
• •* Simplified list of I/E criteria; unabridged list available upon request.