AdV-tk Therapy With Surgery and Chemoradiation for Pancreas Cancer (PaTK01)

Exclusion Criteria

• •Primary hepatic dysfunction including active hepatitis but not to exclude patients due to obstructive jaundice. If obstructive jaundice is clinically significant, bilirubin should be stable or decreasing prior to enrollment.
• •Evidence of clinically significant pancreatitis as determined by the investigator.
• •Patients on corticosteroids or other immunosuppressive drugs
• •Known HIV+ patients
• •Patients with acute infections (viral, bacterial or fungal infections requiring therapy)
• •Pregnant or breast-feeding patients. Female patients of childbearing age must have negative serum or urine pregnancy test within 1 week of beginning therapy
• •Evidence of distant metastatic disease at the time of enrollment or other malignancy (except squamous or basal cell skin cancers) and no prior abdominal radiation therapy or prior treatment for pancreatic cancer
• •Other serious co-morbid illness or compromised organ function