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Keep this study
Lead
University of Toledo Health Science Campus
With
GlaxoSmithKline
The effect of Carvedilol CR on Micro T-Wave Alternans will be assessed in 30 hypertensives with stage 4 or 5 chronic kidney disease utilizing a cross-over design and contrasting no treatment against active treatment periods of 8 weeks.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Adults age 18 and older
Chronic kidney disease
Must be able to do stress test
You may not be if
Must not be mentally disabled
Unable to provide informed consent
Unable or unwilling to comply with study protocol or procedures
Pregnancy or unknown pregnancy status in female of childbearing potential
Participation in any drug trial during the study period
Prior enrollment in this study
Active liver disease
Currently on β-blocker medication at the time of enrollment
Known history of asthma exacerbation with β-blocker therapy
Second or third degree AV nodal block or bradycardia with resting heart rate \<50 bpm
Prior allograft organ transplantation
Planned allograft transplantation reasonably foreseen within the active treatment period
Electrocardiographic left or right bundle branch block
Permanent implanted pacemaker
Atrial fibrillation
Ongoing treatment with any of the following medications: sotalol (Betapace), azimilide (Stedicor), quinidine (Quinidex), disopyramide (Norpace), dofetilide (Tikosyn), ibutilide (Corvert), procainamide (Procanbid), bepridil (Vascor), amiodarone (Cordarone), clarithromycin (Biaxin), erythromycin (Eryc), halofantrine (Halfan), pentamidine (Pentam), sparfloxacin (Zagam), domperidone (Motilium), droperidol (Inapsine), chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), thioridazine (Mellaril), pimozide (Orap), arsenic trioxide (Trisenox), cisapride (Propulsid), lidoflazine (Clinium), and methadone (Dolophine)
Clareo Health | Carvedilol and Micro T-Wave Alternans in Hypertensives With Chronic Kidney Disease
