more than one previous chemotherapy regimens for advanced disease

prior anthracycline chemotherapy (\> 250 mg/m2 adriamycin)

radiotherapy completed within 14 days prior to Day 1 of treatment

incomplete healing from prior oncologic or other major surgery

signs of neurological symptoms consistent with spinal cord compression

any evidence of clinically active interstitial lung disease (patients with chronic stable

IRESSA™ (Gefitinib) in Breast Cancer Patients