Sulforaphane as an Antagonist to Human PXR-mediated Drug-drug Interactions

Exclusion Criteria

• •Medical history of gastrointestinal, hepatic, or renal disorders
• •Pregnancy or lactation
• •Known allergies/intolerances to any foods used in the feeding trial
• •Weight loss or gain greater than 4.5 kg within the past year
• •Major changes in eating habits within the past year (e.g. adoption of a faddish diet)
• •Antibiotic use within the past 3 months
• •Body weight greater than 150% of desirable
• •Exercise patterns that require or result in major changes in diet
• •Current use of prescription medication (including oral contraceptives)
• •Current use of over-the-counter medications and herbal supplements
• •Regular exposure to passive smoke
• •Occupational exposure to smoke or organic solvents
• •Food dislikes that would preclude participation in the feeding trial
• •Alcohol intake of greater than 2 drinks/day (2 drinks=720 mL beer, 240 mL wine, or 9 mL spirits). Additionally, before the trial, participants will have a blood draw to be sent to the UW Medical Center Lab for liver and kidney functions profile and pregnancy test for women. Those with abnormal test results will be excluded as well as pregnant women.