Atorvastatin in Pulmonary Hypertension

Exclusion Criteria

• •PAH related to other etiologies (Groups 2, 3 and 5 pulmonary hypertension)
• •A forced expiratory volume in one second/ forced vital capacity bellow 50% or a total lung capacity of less than 60 percent predicted value
• •A 6-minute walk distance of less than 100 or more than 460 m
• •A positive acute vasodilator response
• •Current treatment with calcium-channel blockers or specific therapy (endothelin receptor antagonist, phosphodiesterase-5 inhibitor, or prostacyclin)
• •Inability to perform 6-minute walk test
• •Serum transaminase level three times above the upper limit of normal
• •Creatine kinase level five times above the upper limit of normal
• •Previously diagnosed heart disease such as serious cardiac arrhythmias, unstable angina pectoris, myocardial infarction
• •History of transient ischemia attack or stroke within three months
• •Bleeding disorder
• •Positive pregnancy test or breastfeeding practice
• •History or suspicion of inability to cooperate