Prospective, Multicenter Study of the Efficacy and Tolerance of Tacrolimus on Refractory Nephrotic Syndrome (RNS)

Exclusion Criteria

• •1. Inability or unwillingness to provide written informed consent ;
• •2. Known hypersensitivity or contraindication to tacrolimus, cyclophosphamide, azathioprine, corticosteroids;
• •3. Usage of immunosuppression therapy (MMF, CTX, CysA, MTX ect) for more than 1 week within 1 month prior to first randomization;
• •4. Pregnancy, nursing or use of a non-reliable method of contraception;
• •5. Continuous dialysis starting more than 2 weeks before randomization into the induction phase and/or continuous dialysis with an anticipated duration of more than 8 weeks;
• •6. Previous kidney transplant or planted transplant;
• •7. Scr \> 4mg/dl (353umol/L);
• •8. Active hepatitis, with liver dysfunction;
• •9. Diagnosed DM;
• •10. Participation in another clinic trial and/or receipt of investigational drugs within 4 weeks prior to screening .