Phase II Trial of Neoadjuvant Temozolomide in Melanoma Patients With Palpable Stage III or IV Disease Undergoing Complete Surgical Resection

Exclusion Criteria

• •Uveal or mucosal melanoma
• •Patients with melanoma deemed not amenable to surgical resection or who are not surgical candidates for medical reasons
• •Frequent vomiting or medical conditions that could interfere with oral medication intake
• •Serious infection requiring antibiotics, or nonmalignant medical illnesses that are uncontrolled or whose control might be jeopardized by the complications of this therapy
• •Pregnancy or nursing
• •History of HIV infection even if on HAART as TMZ leads to CD4+ T cell leukopenia
• •Concurrent use of high dose vitamins and herbs
• •Other on-going investigational therapy, concurrent chemotherapy, immunotherapy or radiotherapy