An Evaluation of Safety and Feasibility Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Adolescents With Depression

Exclusion Criteria

• •Current Diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder, mental retardation, pervasive developmental disorder, somatoform disorder, dissociative disorder, posttraumatic stress disorder, obsessive-compulsive disorder, eating disorders, antecedents of autism, and all personality disorders.
• •Active substance dependence (except nicotine) in the past 12 months.
• •Subjects with a history of head trauma, unprovoked seizure history, seizure disorder, or family history of treatment resistant epilepsy.
• •Suspected pregnancy or pregnancy as confirmed by a urine pregnancy test at screening.
• •History of failure to respond to ECT.
• •Metal in the head (except in the mouth), implanted medication pump, cardiac pacemaker.
• •Prior brain surgery.
• •Risk for increased intracranial pressure such as brain tumor.
• •Unable to obtain motor threshold in the subject or motor threshold too high, such that 120% MT cannot be obtained (i.e. \>84% of device output).
• •Significant change or increase in antidepressant medications within the last six weeks.
• •Change in psychiatrist, psychologist, or therapist within the last four weeks.
• •Suicide attempt within the past three months.
• •Any suicide attempt or suicidal intent during the study will terminate involvement in this study.
• •Subjects currently on stimulant, antipsychotic, atypical antidepressant or tricyclic antidepressant medications.
• •Unstable medical or neurological conditions that may include hematological, infectious (such as Human immunodeficiency virus \[HIV\] positive patients) metabolic, or cardiovascular conditions that may preclude safe participation in trial.
• •Subjects undergoing anticoagulant, immune suppressive and 1 or chemotherapy, or those who received any of these therapies \</=3 months before enrollment in the study
• •Subjects with intra-cardiac lines