About Pricing FAQs Blog

Loading clinical trials...

Your health journey, clearly organized.

Find Clinical Trials →

Legal

Privacy Policy
Terms of Service

© 2026 Clareo Health. All rights reserved.

Back to clinical trial search

COMPLETEDPhase 3NCT00572039

Improving Function in Age-Related Macular Degeneration

This randomized, controlled clinical trial will test the efficacy of Problem-Solving Treatment (PST) to improve vision function in older persons with age-related macular degeneration (AMD). AMD is a h...

Lead sponsor: Thomas Jefferson University•1 U.S. locations•View source on ClinicalTrials.gov

Clareo plain-language summary

What this study is about

Generating AI summary...

Save this trial guide to your notes

Keep your clinical trial research organized — questions to ask, what to expect, and key details.

Sponsors

Lead Sponsor

Thomas Jefferson University

Collaborators

Dartmouth College
Johns Hopkins University

The primary hypothesis will address treatment group differences in Targeted Vision Function at 3-months, and secondary hypotheses will the long-term effect (6-months) of Problem Solving Treatment (PST) on TVF and vision-related quality of life.

Age

65 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Being at least 65 years old
•Having bilateral Age-Related Macular Degeneration (AMD) (atrophic or neovascular)
•Having a best corrected visual acuity of 20/70 or worse
•Moderate difficulty in at least one valued vision functional goal

Exclusion Criteria

•Ophthalmologic Criteria. Patients who have uncontrolled glaucoma (continued visual field loss and increase in optic nerve cupping), diabetic retinopathy (due to macular edema), or cataracts for which surgery within 6 months is likely will not be eligible to participate. This information will be obtained from patients' ophthalmology charts and discussion with the patient's ophthalmologist.
•Cognitive Impairment Criteria. Cognitive functioning will be evaluated by the Project Director during the telephone screen (see Chapter 9). Patients with cognitive impairment will not be eligible to participate.
•Health Criteria. Patients with life-threatening illness (e.g., terminal cancer, need for oxygen) will not be eligible to participate. Information regarding heath status will be gleaned from patient's ophthalmology charts.

Related studies

National Eye Institute Biorepository for Retinal Diseases

NCT01496625 · Age-Related Macular Degeneration, Diabetic Retinopathy, and more

RECRUITINGPhase 2

Phase 2 Study of ADX-038 in Participants With Geographic Atrophy

NCT06990269 · Geographic Atrophy Secondary to Age-related Macular Degeneration

RECRUITINGPhase 1/2

Phase 1b/2a Study of EYC-0305 in Patients With Neovascular Age-related Macular Degeneration

NCT07587515 · Neovascular (Wet) Age-Related Macular Degeneration

RECRUITINGPhase 1

Safety of BBC1501 Intravitreal Injection in Patients With Neovascular Age-Related Macular Degeneration (nAMD)

NCT05803785 · Age-Related Macular Degeneration

RECRUITINGEARLY Phase 1

The Role of Occupational Therapy for Improving Medication Management for Persons With AMD, DR and Glaucoma

NCT06593405 · Age-Related Macular Degeneration

View all related studies →

Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: April 15, 2025Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE3

Enrollment241

Start dateAug 2005

Last updatedApr 15, 2025

Condition

Age-Related Macular Degeneration

Locations shown

Thomas Jefferson University

Philadelphia, Pennsylvania

For caregivers

Use Clareo to keep notes, questions, trial details, and next steps organized before and after appointments.

Start free trial →

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 15, 2025Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions