Age

18–60

Sex

ALL

Healthy volunteers

Not accepted

Age ≥ 18 et ≤ 60 and male and female
Diffuse large B cell lymphoma according to WHO classification phénotype B CD 20 +
Stage I et II tumor bulk \> 7 cm and stage III et IV Ann Arbor.
Non previously treated
HIV négative
Signed informed consent

Age \< 18 and/or \> 60 ans
NHL not DLBCL
Lymphoblastic Lymphoma
Burkitt's Lymphoma
Low grade Lymphoma transformed
Primary CNS Lymphomal
Post- transplantation Lymphoma
CD20 negative
Ann Arbor stage I or II without tumor bulk \> 7 cm
Previous treatment
HIV positive
Contre-indication to Rituximab use according to SmPC
Contre-indication to high dose chemotherapy due to organ failure not related to the lymphoma
Cancer or history of cancer with the exception of in situ cancer of the cervix or non-invasive skin epithelioma
Patient not able to understand the proposed treatments
Refusal to sign the informed consent

Diffuse Large B Cell Lymphoma of the Adult: Randomization Between High Dose Chemotherapy With Rituximab and CHOP 14-Rituximab