Finding studies
Finding studies
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Lead
Mirati Therapeutics Inc.
MGCD0103 and FB-MGCD0103 belong to a class of drugs known as histone deacetylase inhibitors (also called HDAC inhibitors). Azacitidine belongs to a class of anti-cancer drugs known as DNA de-methylating agents. Azacitidine (Vidaza®) was approved by the Food and Drug Administration (FDA) in 2004 for the treatment of myelodysplastic syndromes (MDS). The combination of MGCD0103 and azacitidine has been given to about 50 people with leukemia or MDS in other clinical studies. This is the first study where the combination will be tested in people with lymphoma. Specifically, the study is designed to understand the following: * How long single doses of TA-FB-MGCD0103, FB-MGCD0103 and MGCD0103 stay in the body, OR * How long different doses of TA-FB-MGCD0103 and FB-MGCD0103 stay in the body; and * How long MGCD0103 stays in the body when given with azacitidine; and * What effect MGCD0103 and azacitidine have on the body and the study subject's type of lymphoma; and * If the genetic and chemical make-up of the study subject's blood and/or tumor play a role in how she/he responds or does not respond to MGCD0103 and azacitidine.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
