Known hypersensitivity to Irbesartan

Hypertension grade 3

History of clinical vascular events such as TIAs, stroke, peripheral arterial disease

Coronary artery disease

Renal insufficiency (creatinine serum levels \> or = 1.2 mg/dL)

Presence of clinical heart failure

Asthma and COPD

Valvular cardiopathy clinically relevant

Current therapy with antioxidant drugs, statins

Therapy with AIIRA for at least 3 months during the last semester

Presence of any acute illness or major trauma in the last 8 weeks

History of a chronic inflammatory disease such as rheumatoid arthritis, immune disorders or connective tissue disease.

The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Effect of the Angiotensin II Receptor Antagonist Irbesartan on Biochemical and Functional Markers of Endothelial Dysfunction in Patients With Hypertension