AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Dupuytren's Contracture

Exclusion Criteria

• •Had a chronic muscular, neurological, or neuromuscular disorder that affected the hands.
• •Had received a treatment for Dupuytren's contracture, including surgery (fasciectomy or surgical fasciotomy), needle aponeurotomy/fasciotomy, or injection of verapamil and/or interferon on the selected primary joint within 90 days before the first dose of study drug.
• •Had a known recent history of stroke, bleeding, a disease process that affected the hands, or other medical condition, which in the investigator's opinion, would make the subject unsuitable for enrollment in the study.