Primary Outcome Measures :
* Airway inflammation (% induced sputum eosinophils)
Secondary Outcome Measures:
* Perception of induced respiratory symptoms
* Airway response to methacholine and AMP, and perception scores
* Diurnal variation in Peak Expiratory Flows
* Profile of regulatory T cells in the peripheral blood
* Changes in these parameters over time (baseline, 6 months, 1 and 2 years)