Tiotropium In Exercise

Exclusion Criteria

• •1. Significant diseases other than COPD such as history of life-threatening pulmonary obstruction, thoracotomy with pulmonary resection, interstitial lung disease, CF, pulmonary thromboembolic disease, clinically evident bronchiectasis, active tuberculosis, or known moderate to severe renal impairment
• •2. Clinical history of asthma
• •3. Use of supplemental oxygen therapy
• •4. Respiratory tract infection or COPD exacerbation in the 6 weeks prior to Visit 1 or during the washout period prior to Visit 3 (may randomize 6 weeks after recovery)
• •5. Recent history (\<= 12 months) of myocardial infarction
• •6. Unstable or life-threatening cardiac arrhythmia
• •7. Malignancy treated with radiation therapy or chemotherapy in the last 5 years
• •8. Pregnant or nursing women
• •9. Known hypersensitivity to anticholinergic drugs or any component of the study medications
• •10. Participation in pulmonary or cardiac rehab program within 13 weeks of Visit 1
• •11. Estimated life expectancy \< 2 years
• •12. Symptomatic prostatic hyperplasia or bladder neck obstruction
• •13. Known narrow-angle glaucoma
• •14. Any condition that is contraindicated for exercise
• •15. Orthopaedic, muscular, neurological or cardiac disease that would interfere with regular participation in aerobic exercise or with exercise testing
• •16. Body mass index \< 18 kg/m2 or \>35 kg/m2 list truncated for space