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COMPLETEDNANCT00497016

Does Statin Therapy Reduce Sympathoexcitation in Hypertension?

A number of patients with hypertension have increased central sympathetic activity. Statins seem to inhibit central sympathetic output. This study assesses the effect of statins on central sympathetic...

Lead sponsor: Radboud University Medical Center•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Radboud University Medical Center

Collaborators

ZonMw: The Netherlands Organisation for Health Research and Development

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•(Known) hypertension
•stable drug therapy for at least 2 months
•age 18-70 jaar
•BMI 18-35 kg/m2
•Sinusrhythm

Exclusion Criteria

•Recent cardiovascular event \<6 mnd
•Plasma Creatinin:
•female: \>120 mmol/L
•male: \>133 mmol/L
•use of:
•tricyclic antidepressants
•alpha-1 -and/or alpha-2 blockers
•disease of the autonomic nervous system (Parkinsons disease, Shy- Drager syndrome, etc)
•Albuminuria \>300 mg/dag

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: September 30, 2008Terms

Trial snapshot

StatusCOMPLETED

PhaseNA

Enrollment13

Start dateMay 2007

Last updatedSep 30, 2008

Condition

Locations shown

Radboud University Medical Center Nijmegen

Nijmegen

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 30, 2008Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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