Lead Sponsor

Royal Brompton & Harefield NHS Foundation Trust

Collaborators

Age

All ages

Sex

ALL

Healthy Volunteers

No

•Written informed consent.
•Patient has typical angina pectoris - stable or unstable symptoms.
•Atherosclerotic coronary artery disease demonstrated with selective coronary angiography with a significant lesion present in at least two of the principal epicardial vessel systems.
•Revascularisation procedure clinically indicated.
•Nominated trial surgeon accepts the patient for CABG.
•Nominated trial interventionist accepts the patient for PTCA and stent.
•At least one identified lesion suitable and targeted for primary stent implantation.
•A procedure for the completion of either revascularisation strategy can be performed within 6 weeks of randomisation.

•Previous CABG procedure or other thoracotomy.
•Previous coronary interventional procedure (of any type).
•Intervention on any cardiac valve scheduled for the index revascularisation procedure.
•Excision or other intervention on the myocardium scheduled for the index revascularisation procedure.
•Intervention on the great vessels, carotid arteries or aorta scheduled for the index revascularisation procedure.
•Absent autologous graft material.
•Non-cardiac disease influencing survival.
•Acute myocardial infarction in the 48 hours preceding the proposed revascularisation procedure.
•Participation in any other study that would involve deviation from the routine local management of a revascularisation procedure.
•Allergy to anti-platelet agents in local use.
•Language or other communication barrier.
•Follow-up for two years not possible / Patient unreliable.