One vs. Three Hyperbaric Oxygen Treatments for Acute Carbon Monoxide Poisoning

Exclusion Criteria

• •Pregnancy
• •Age \< 18 years or \> 79 years
• •Complication during first hyperbaric oxygen session precluding subsequent hyperbaric oxygen.
• •Intentional CO poisoning
• •Unable to obtain informed consent
• •Moribund patient
• •Concomitant smoke inhalation with cyanide poisoning
• •Bleomycin use within two weeks of study enrollment
• •Intracardiac defibrillator that cannot be deactivated
• •Non-English speaking
• •Unlikely to return at 6 weeks
• •History of central nervous system (CNS) disease (i.e., Alzheimer's, Parkinson's, dementia, demyelinating disease (MS), etc.)
• •History of prior brain injury (i.e., stroke, traumatic brain injury)
• •Presence of chronic debilitating disease likely to result in death within 12 months (i.e., kidney failure on dialysis, heart failure)
• •Subject has a significant medical condition or conditions that would interfere with the treatment, safety, or compliance with the protocol.
• •Intubated subjects
• •Subjects requiring greater than 50% oxygen by non-rebreather facemask or exhibiting evidence of respiratory compromise or heart failure