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Lead
University of Chicago
We will recruit subjects with OSA about to undergo adenotonsillectomy and collect a blood sample and portion of their tonsils after the induction of general anesthesia. The mononuclear cells will be isolated from both these tissues and stimulated with different markers and cytokines assayed and compared. We will also recruit patients with no symptoms of OSA undergoing unrelated elective surgery and ascertain the absence of OSA by having the parents fill out a sleep questionnaire. We will then collect blood samples from these patients after the induction of anesthesia and examine the cytokine secretion profile and compare it to that of the children with OSA.
Age
1–12
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
OSA documented by polysomnography and clinical symptoms.
Patients with no symptoms of OSA and negative sleep questionnaire.
You may not be if
Significant systemic disease except mild asthma
Clareo Health | Cytokine Profiles in Children With Obstructive Sleep Apnea