Histologically confirmed metastatic breast cancer

All patients were required to give written informed consent.

Prior treatment with chemotherapy, hormonal therapy, immunotherapy or local radiotherapy was allowed (except gemcitabine or platinum agents).

Patients were required to have at least one bidimensionally measurable lesion outside a previous radiation port.

Age ≥ 18 years

Karnofsky Performance status ≥ 70 %

Minimal life expectancy of 12 weeks

Adequate haematological, renal, cardiac and hepatic function:

1. Leukocyte count ≥ 3.0 x 109/l

2. Absolute neutrophil count ≥ 2.0 x 109/l

3. Platelet count ≥ 100 x 109/l

4. Haemoglobin ≥ 8 g/dl

5. Total serum bilirubin ≤ 1.25 x upper limit of normal (ULN) In presence of liver metastasis ≤ 3 x ULN

6. Transaminase (ALT,AST) level ≤ 3 x ULN In presence of liver metastasis ≤ 5 x ULN

7. Alkaline phosphatase level ≤ 2.5 x ULN

8. Creatinine clearance was required to exceed 60 ml/min.

Gemcitabine + Carboplatin in Breast Cancer