Phase 2a Obesity Study of Oral Doses of Oleoyl-Estrone (MP-101)

Exclusion Criteria

• •Be pregnant or nursing
• •Have taken exclusionary medication in the past 30 days
• •Have any clinically significant abnormal laboratory test as determined by the investigator
• •Have a clinically significant illness during the 30 days before enrollment
• •Have a history of testing positive for Hepatitis B virus, Hepatitis C virus, or HIV
• •Have a confirmed diagnosis or history of cancer, with the exception of nonmelanoma skin cancer
• •Have a previous diagnosis of diabetes
• •Be otherwise unsuitable for the study, in the opinion of the investigator
• •Have an allergy to safflower seeds or its byproducts (e.g., safflower oil)
• •Have any postmenopausal bleeding within the last 6 months
• •Have been involved in a formal or informal (self-imposed) diet regimen within the last 30 days
• •Currently working night shifts
• •Have a history of known multiple miscarriages