Efficacy and Safety of Natto Extract

Inclusion Criteria

• •1. Men and non-pregnant women who are at least 20 and younger than 70 years of age.
• •2. Subjects who are, in the opinion of the Investigator, able to comply with the requirements of the study.
• •3. Subjects who have been adequately informed of the nature and risks of the study and who have given written informed consent prior to receiving investigational product.
• •Group-specific inclusions criteria:
• •Group A:
• •1. Subjects have no risk factors of cardiovascular diseases (see Group C) or chronic renal diseases in the history.
• •2. Male subjects have Creatinine≦1.4 mg/dl; Female≦1.3 mg/dl.
• •Group B:
• •1\. Patients have been receiving dialysis at the same institute for at least 3 months.
• •Group C:
• •1. Patients have coronary artery disease (CAD); OR
• •2. Patients have peripheral arterial occlusive disease (PAOD); OR
• •3. Patients have history of stroke; OR
• •4. Patients have history of transient ischemic attack (TIA); OR
• •5. Patients have history of pulmonary embolism (PE); OR
• •6. Patients have history of deep vein thrombosis (DVP); OR
• •7. Patients have more than 2 major risk factors of cardiovascular disease (CVD) listed by National Health Insurance guidelines such as hypertension, smoking, diabetes mellitus (DM), atrial fibrillation (AF), lipid disorder, overweight, physical inactivity, etc.