A Study To Investigate The Metabolism Of GW876008 In Smokers Compared To Non-Smokers.

Exclusion Criteria

• •Any serious medical disorder or condition.
• •Any clinically significant laboratory abnormality.
• •History of psychiatric illness.
• •Any history of suicidal attempts or behavior.
• •Active peptic ulcer disease.
• •Positive faecal occult blood.
• •Current or recent (within one year) gastrointestinal disease; a history of malabsorption, oesophageal reflux, irritable bowel syndrome; frequent (more than once a week) occurrence of heartburn; or any surgical intervention (e.g., cholecystectomy) which would be expected to influence the absorption of drugs.
• •Female subjects who are currently or who are planning to become pregnant or who are lactating (from screening through at least 8 weeks after receiving study drug).