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TERMINATEDPhase 2NCT00406575

Recombinant Human Relaxin for the Treatment of Decompensated CHF

Two doses of relaxin will be compared to placebo for the treatment of patients with decompensated CHF

Lead sponsor: Corthera, Inc.(formerly BAS Medical, Inc.), a member of the Novartis group of companies•2 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Corthera, Inc.(formerly BAS Medical, Inc.), a member of the Novartis group of companies

Pilot clinical data suggest that recombinant human relaxin may be effective in treating patients with decompensated CHF. This study will randomize patients in blinded manner to one of two doses of intravenous relaxin or placebo. Serial evaluations will include cardiac and renal function, as well as safety and tolerability.

Age

19 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Hospitalization
•Decompensated chronic CHF (NYHA Class III-IV)
•LVEF \< 35%
•PCWP \> 22 mmHg
•CI \< 2.3 L/min/m2

Exclusion Criteria

•Acute CHF
•Acute coronary syndrome
•Hypotension or shock
•Recent stroke
•Allergy or sensitivity to test agents
•Significant confounding conditions or medications

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: May 7, 2014Terms

Trial snapshot

StatusTERMINATED

PhasePHASE2

Enrollment11

Start dateNov 2006

Last updatedMay 7, 2014

Condition

Congestive Heart Failure (CHF)

Locations shown

Russian Scientific Centre of Surgery n.a. B.V.Petrovsky of Russian Academy of Medical Sciences

Moscow

Educational Scientific Medical Center of the General Management Department of the President of Russian Federation. City Clinical Hospital №51

Moscow

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 7, 2014Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions