Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Maastricht University Medical Center
With
AstraZeneca
Cystic Fibrosis Foundation
Age
5–46
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Asthma is defined as a chronic inflammatory disorder, leading to recurrent episodes of wheezing, breathlessness, chest tightness, and/or coughing, based on variable airway obstruction \[18\]. Children with docter-diagnosed asthma known at the department of Paediatric Pulmonology, were recruited from the University Hospital Maastricht. Atopic and not atopic asthmatic children were allowed; treatment with inhalation corticosteroïd (ICS) was not obliged.
Children known with CF were recruited from University Hospital Maastricht. CF was defined as a combination of typical clinical features and an abnormal sweat test (Chloride \> 60 mM). CF lung disease was treated according to the CBO consensus ref. Main aspects of treatment were:
* antibiotic treatment,
* agents to promote airway secretion clearance, such as DNase,
* bronchodilators, and,
* physiotherapy. All alternations of medical therapy were allowed and accurately documented.
You may not be if
Diseases that may interfere with the results of the study (e.g. upper airway infection, cor vitium, anatomic abnormalities of the airway and other chronic inflammatory diseases, such as Morbus Crohn and rheumatoid arthritis),
Mental retardation,
Inability to perform measurements properly,
Active smoking and,
Use of the following medication: papaverin, sodium nitroprusside, angiotensin-converting enzyme (ACE) inhibitors, oxymetazoline, L-arginine, or nitric oxide synthase (NOS) inhibitors
Clareo Health | FLAME: Airway Inflammation Monitoring in Asthma and Cystic Fibrosis
