Radiation Therapy After Prostatectomy in Treating Patients With Stage III Prostate Cancer

Inclusion Criteria

• •PROTOCOL ENTRY CRITERIA:
• •-Disease Characteristics--
• •Pathologically documented Stage C (T3 N0 M0) adenocarcinoma of the prostate following radical prostatectomy and pelvic lymphadenectomy for clinical Stage A/B disease
• •Ineligible for SWOG protocols of higher priority
• •At least 1 of the following on pathologic examination:
• •* Presence of cancer in the seminal vesicles
• •* Evidence of cancer at the inked surgical margin of the prostate
• •* Extension of tumor beyond the prostatic capsule
• •Negative preoperative metastatic survey within 6 months prior to registration, including the following:
• •* Normal bone scan
• •* No palpable evidence of extraprostatic tumor extension
• •Bilateral lymph node dissection histologically negative for cancer
• •Nodal sampling not required with the following stage/biopsy specimen Gleason score/preoperative PSA:
• •* Stage T1a/2-6/\<10 ng/ml
• •* Stage T1b-c/2-5/\<10 ng/ml
• •* Stage T2a/2-6/\<10 ng/ml
• •* Stage T2b/2-6/\<6 ng/ml
• •* Stage T2c/2-6/\<4 ng/ml
• •Free from the following postoperative complications:
• •* Total urinary incontinence
• •* Intraoperative rectal injury
• •* persistent urinary extravasation
• •* Pelvic infection
• •Concurrent registration on protocol SWOG-9205 (serum repository protocol) optional
• •Concurrent registration on protocol SWOG-8994 (quality-of-life study) required of English-speaking and Spanish-speaking patients enrolled by SWOG
• •-Patient Characteristics--
• •Age: Any age
• •Performance status: SWOG 0-2
• •Life expectancy: At least 2 years
• •Hematopoietic:
• •* WBC at least institutional LLN
• •* Platelets at least institutional LLN
• •Hepatic: SGOT no more than 2 x ULN
• •Other: No second malignancy within 5 years except adequately treated nonmelanomatous skin cancer
• •-Prior Concurrent Therapy--
• •Chemotherapy: No prior chemotherapy for prostate cancer
• •Endocrine therapy: No more than 3 months of hormonal therapy prior to prostatectomy allowed
• •Radiotherapy: No prior radiotherapy for prostate cancer
• •Surgery: Radical prostatectomy and pelvic lymphadenectomy within 16 weeks prior to registration required