Iron Supplementation in Heart Failure Patients With Anemia: The IRON-HF Study

Exclusion Criteria

• •Any clinically overt bleeding: gastrointestinal bleeding, hypermenorrhea, history of peptic ulcer without evidence of healing or inflammatory intestinal diseases;
• •Uncorrected hypothyroidism;
• •Other inflammatory, neoplastic or infectious disease;
• •Serum creatinine \> 1,5 mg/dl;
• •Previous intolerance to oral elemental iron compounds;
• •HF due to alcoholic cardiomyopathy, current regular drinker of alcoholic beverages or HF due to peripartum cardiomyopathy;
• •Recent admission for decompensated HF (last month)
• •Recent myocardial revascularization procedures (last 3 months);
• •Recent ACS, stroke or TIA (last 3 months);
• •Active or metastatic neoplastic disease with life expectancy of less than a year;
• •Patients in heart transplantation list;
• •Patients that had participated in any other clinical trial or study within the last month;
• •Pregnant or lactating women;
• •Pre-menopausal women that are not using any effective method of contraception;
• •Patients using prohibited medications or that have not yet accomplished the wash-out period;
• •Patients currently participating in cardiovascular rehabilitation programs.