Lead Sponsor

The Alfred

Collaborators

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•males and females over 18 years of age
•Documented CHF (NYHA class II-IV symptoms)
•Airflow obstruction defined as patients with symptomatic obstructive respiratory disease as manifest by any of the following Symptoms of wheeze, primarily attributed to airflow obstruction Requirement for intermittent or regular bronchodilator therapy FEV1 less than 70% predicted pre-salbutamol
•Confirmed written informed consent.
•Clinically indicated to receive β-blockade.
•No evidence of heart block on ECG.
•Patients will be in one of the following categories:
•Currently on carvedilol Currently on Toprol-XL or Metoprolol tartrate Currently on bisoprolol Clinically indicated to receive β adrenoceptor blockade but not currently prescribed a β-blocker.

•Women lactating, pregnant or of childbearing potential not using a reliable contraceptive method.
•Patients who had received an investigational new drug within the last 4 weeks.
•Patients with a history of a psychological illness or condition such as to interfere with the patient's ability to understand the requirements of the study.
•Laboratory parameters:
•Creatinine \>0.30 mmol/l Liver function tests 3x ULN
•Recent (\<12 months) myocarditis

Related studies

NCT06222762 · Heart Failure

NCT06052475 · Pacing-Induced Cardiomyopathy, Heart Failure

NCT06675552 · Heart Disease, Heart Failure, and more

NCT05666518 · Chronic Heart Failure

NCT05677100 · Heart Failure, Cardiorenal Syndrome, and more

A Comparison of the Effect of Carvedilol and Metoprolol on Airways Tone in Patients With Heart Failure