Lead Sponsor

Novartis

Age

30 - 65 years

Sex

ALL

Healthy Volunteers

No

•Must be able to complete a 3-week wash-out of current anti-diabetic medication
•Cannot take any medications which may alter gastric motility except for cardiac medication at a stable dose
•Must discontinue beta-blockers and lipid lowering drugs
•Blood glucose criteria must be met
•BMI in the range 30-35

•History of type 1 diabetes, diabetes resulting from pancreatic injury, or secondary forms of diabetes
•Need for insulin within 3 months or patients on thiazolidinediones
•Patients taking a sulfonylurea or metformin who cannot safely discontinue medication for the duration of the study
•Significant concomitant disease or complications of diabetes
•Patients with any history of gastrointestinal surgery or positive gastrointestinal symptons
•High tryglycerides as defined by the protocol
•Smokers who cannot abstain from smoking during the treatment periods