A Study of Zoledronic Acid in the Prevention of Cancer Therapy-induced Bone Loss

Exclusion Criteria

• •Prior treatment with bisphosphonates and estrogens or treatments for osteoporosis in addition to calcium and vitamin D
• •Severe physical or psychological concomitant diseases and other known concurrent, severe medical disorder jeopardizing the life of the patient in the immediate future (e.g., myocardial infarction in previous six months, angina pectoris despite treatment, uncontrolled severe arterial hypertension, progressive cardiac or respiratory failure)
• •Known hypersensitivity to bisphosphonates
• •Abnormal renal function
• •Current active dental problems including infection of the teeth or jawbone (maxilla or mandibular); dental or fixture trauma, or a current or prior diagnosis of osteonecrosis of the jaw (ONJ), of exposed bone in the mouth, or of slow healing after dental procedures and recent (within 6 weeks) or planned dental or jaw surgery (e.g. extraction, implants)