Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
GlaxoSmithKline
Age
35–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Newly diagnosed as essential hypertension or not treated in the past 2 weeks(If the subject took medication in the past 2 weeks, a wash-out period of at least 2 weeks will be completed prior to performing screening (week -2) assessments)
Mean seated SBP at screen visit = 130mmHg (as measured by a mercury sphygmomanometer)
Type 2 diabetes (American Diabetes Association criteria 2004) and HbA1C \<11%
Agree to practice acceptable contraceptive measures during the study, and for 30 days after the last dose of study medication is taken if the subject a female of child-bearing potential
Provide written informed consent
You may not be if
Mean seated SBP of \> 180 mmHg
Known or suspected secondary hypertension
Anemia defined by haemoglobin concentration \< 10.0 g/dL
Hemoglobinopathy or peripheral vascular disease
Clinically significant renal or hepatic disease (i.e., subjects with serum creatinine = 2.0 mg/dL; Alanine aminotransferase, Aspartate aminotransferase, total bilirubin, or alkaline phosphatase \> 2.5 times the upper limit of the normal reference range)
Unstable or severe angina, coronary insufficiency, or any congestive heart failure requiring pharmacologic treatment
Chronic disease requiring intermittent or chronic treatment with oral, intravenous, or intra-articular corticosteroids (i.e. only use of topical, inhaled or nasal corticosteroids is permissible)
Female who is lactating, pregnant, or planning to become pregnant
clinically significant abnormality identified at screening which in the judgement of the investigator makes the subject unsuitable for inclusion in the study (e.g. physical examination, laboratory tests, or electrocardiogram etc.)
Acute or chronic metabolic acidosis or a history of diabetic ketoacidosis
Clareo Health | Lacidipine In Mild To Moderate Essential Hypertension Patients With Type 2 Diabetes In Korea
