Cinacalcet to Treat Familial Primary Hyperparathyroidism

Exclusion Criteria

• •Criteria for exclusion or removal
• •1. Age less than 18 years
• •2. Pregnancy
• •3. Creatinine greater than 1.4
• •4. SGOT or SGPT greater than twice normal
• •5. Indications for current surgery:
• •1. Hyperparathyroidism
• •* Albumin-adjusted serum calcium level higher than 3.0 mmol/L (12.0 mg/dL)
• •* Kidney stones
• •* Significant PTH-induced bone disease
• •* Age below 50 is not considered as absolute indication for parathyroid surgery herein
• •2. Enteropancreatic neuroendocrine neoplasia
• •* Single lesion meeting criteria for surgery
• •* Need for debulking surgery for obstructive or other complications
• •* Acute abdominal complications of any kind
• •* Inability of control on PPI in case of ZES
• •6. Chemotherapy within last 6 months
• •7. Lactating females
• •8. Patients with contraindications for MRI study, including pacemakers, vascular clips, implants, foreign bodies etc., as per NIH-MRI Safety Guideline.