any serious disorder that could limit the ability of the patient to participate in the study

significant cardiovascular disease (angina, myocardial infarction, cerebrovascular disease, or significant arrhythmia in the preceding 6 months)

uncontrolled diabetes mellitus (serum glucose level ≥140 mg/dl)

insulin dependent diabetes mellitus (type I)

secondary hypertension

Efficacy and Safety Study of S-Amlodipine Gentisate Compared to Amlodipine Besylate to Treat Mild-to-Moderate Hypertension