Age

40–70

Sex

ALL

Healthy volunteers

Accepted

instable COPD during the month before visit 1
usage of corticosteroids during the month before visit 1
significant pulmonary diseases other than COPD
a history of cancer within the last 5 years (basal cell carcinoma or cutaneous squamous cell carcinoma allowed)
a recent history of myocardial infarction
use of an investigational drug within one month or six half lives (which ever is greater) of visit 1
contra-indications for the use of ipratropium-bromide

Metoprolol and Formoterol in Chronic Obstructive Pulmonary Disease (COPD)