Intracranial disease or epidural disease

Clinically significant cardiac disease

Diabetes mellitus uncontrolled with medication

Pregnant or breast feeding women

Dementia or altered mental status

Known pre-existing clinically significant or uncontrolled disorder of the hypothalamic-pituitary axis, adrenal or thyroid glands

Previous pericarditis

Malabsorption syndrome or uncontrolled gastrointestinal symptoms such as nausea,diarrhea,vomiting

Safety, Pharmacokinetics and Pharmacodynamics of TKI258 in Subjects With Acute Myeloid Leukemia