Controlled Study to Evaluate the Efficacy and Safety of the Treatment With Growth Hormone in Tibia Fractures

Exclusion Criteria

• •Open growth plate on X-rays
• •Known chronic endocrine or metabolic disease including diabetes and severe obesity defined as body mass index (BMI)1 \> 32.0
• •Severe head injury defined as patients who are stuporous or comatose with pupillary enlargement or asymmetry
• •Critically ill patients defined as patients in need of mechanical ventilation (except during surgical procedures) or circulatory support (defined as use of inotropic drugs)