NB1011 Administered by Continuous Infusion in Cancers That Overexpress Thymidylate Synthase (TS)

Exclusion Criteria

• •Tumors that cannot be biopsied or with low level of TS expression
• •Requirement for concomitant anticancer therapy
• •Treatment with another investigational product within 30 days of study entry
• •Pregnant or lactating women
• •Active or uncontrolled serious bacterial, viral, fungal, or parasitic infection.
• •HIV infection
• •Clinically apparent meningeal or central nervous system (CNS) metastases or carcinomatous meningitis