Tumors that cannot be biopsied or with low level of TS expression

Requirement for concomitant anticancer therapy

Treatment with another investigational product within 30 days of study entry

Pregnant or lactating women

Active or uncontrolled serious bacterial, viral, fungal, or parasitic infection.

HIV infection

Clinically apparent meningeal or central nervous system (CNS) metastases or carcinomatous meningitis

NB1011 Administered by Continuous Infusion in Cancers That Overexpress Thymidylate Synthase (TS)