About Pricing FAQs Providers Blog

Loading clinical trials...

Your health journey, clearly organized.

Find Clinical Trials →

Legal

Privacy Policy
Terms of Service

© 2026 Clareo Health. All rights reserved.

Back to clinical trial search

COMPLETEDPhase 4NCT00239551

Effect of Prevacid on Prostaglandin Levels in Patient With Stress Ulcer

The purpose of this study is to measure the prostaglandin levels in patients with stress ulcer and the effect of Prevacid on prostaglandin levels in patients with stress ulcer.

Lead sponsor: Emory University•1 U.S. locations•View source on ClinicalTrials.gov

Clareo plain-language summary

What this study is about

Generating AI summary...

Save this trial guide to your notes

Keep your clinical trial research organized — questions to ask, what to expect, and key details.

Sponsors

Lead Sponsor

Emory University

Collaborators

TAP Pharmaceutical Products Inc.

The prostaglandin system plays an important role in the gastric mucosa to strengthen its resistance against injury. Critically ill patients are at greatest risk of developing stress-related gastric mucosal lesions. Although the levels of prostaglandins in gastric mucosa in patients with stressed animal has been studied, prostaglandin levels in the gastric mucosa in patients with stress ulcer have not been studied and the effect of Prevacid on prostaglandin levels in gastric mucosa from patients with stress ulcer is unknown. We hypothesize that prostaglandin levels are low in the gastric mucosa in patients with stress ulcer, and Prevacid is an effective agents in increasing prostaglandin levels in the gastric mucosa in stress stress ulcer. Comparison(s): The prostaglandin levels in patients who treated with Prevacid for stress ulcer, compared to the prostaglandin levels in patients who treated with H2 blocker for stress ulcer.

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Patients in ICU with documented gastric stress ulcer by endoscopic examination, including patients with H. Pylori infection;
•Patients have no known ulcer within 8 weeks prior to be admitted to ICU;
•Patients not on any PPI for 4 weeks prior to the study;
•Patients or family be consented for the study.

Exclusion Criteria

•Patients have gastric ulcer within 8 weeks prior to be admitted to ICU;
•Patients have gastric cancer confirmed by pathology;
•Patients on one of the PPIs already;
•Patients on any of the Non-steroidal Antiinflammatory Drugs.

Related studies

A Study of Pariet to Prevent Gastric and Duodenal Ulcer Associated With Low-aspirin in Korean Participants With a History of Gastric and Duodenal Ulcer

NCT05208268 · Stomach Ulcer, Duodenal Ulcer

Systematic Assessment and Targeted Improvement of Services Following Yearlong Surgical Outcomes Surveys

NCT02032030 · Heart Attack, Cardiac Arrest, and more

Helicobacter Pylori Sample Collection Protocol Post Therapy Subjects

NCT03060733 · Helicobacter Pylori Infection, Gastric Ulcer, and more

COMPLETEDPhase 4

A Double-blind, Comparative Study in Patients With Gastric Ulcer to Evaluate the Efficacy of Combination Use of E0671 and Rabeprazole Sodium

NCT00125736 · Stomach Ulcer

H. Pylori Testing for Patients With Non-specific Upper Abdominal Pain in the Emergency Department

NCT01376414 · Gastritis, Peptic Ulcer, and more

View all related studies →

Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: July 31, 2013Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE4

Enrollment30

Start dateOct 2005

Last updatedJul 31, 2013

Condition

Locations shown

Emory University School of Medicine

Atlanta, Georgia

For caregivers

Use Clareo to keep notes, questions, trial details, and next steps organized before and after appointments.

Start free trial →

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 31, 2013Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions