Analgesic Effect in Children of Low-Dose Ketamine for Mucositis Treated by Patient-Controlled Analgesia With Morphine

Inclusion Criteria

• •Painful mucositis
• •Child from 5 to 18 years.
• •Presenting mucitis induced by chemotherapy or a conditioning of graft hematopoïetic.
• •A pain not controlled by systematic paracetamol (10mg/kg/4h) or a the propacetamol (20mg/kg/4h).
• •Not presenting a neurological or psychological difficulty at the use of the PCA or a EVA.
• •First morphine amount going back to less 48h, and lass administration dating of more than 4h at the time of the beginning of the perfusion of Ketamine/placebo (EVA \> 30 after stop morphine).
• •Assent signed by the parents and each time possible by the child.