Immediate need for renal replacement therapy.

Treatment resistant oedema.

Need for treatment with corticosteroids, non-steroidal anti-inflammatory drugs, or immunosuppressive drugs.

Proteinuria greater than 10g /24h and/or hypoalbuminaemia less than 28g/L.

Renovascular hypertension

Malignant hypertension

MI, cerebrovascular accident within last year, severe peripheral vascular disease, CHF, chronic hepatic disease.

Angiotensin converting enzyme inhibitors and angiotensin II receptors blockers within one month prior to randomization.

A serum creatinine concentration \>265 ümol/L

Antiproteinuric Effect of Valsartan and Lisinopril