SMS: Substrate Modification Study in Patients Getting an Implantable Cardioverter Defibrillator (ICD)

Exclusion Criteria

• •Age \< 18 years or \> 80 years
• •Protruding left ventricular (LV) thrombus on pre-ablation echocardiogram
• •Acute myocardial infarction within the preceding 2 months
• •Class IV New York Heart Association (NYHA) heart failure
• •Valvular heart disease or mechanical heart valve precluding access to the left ventricle
• •Unstable angina
• •Cardiac surgery within the past 2 months
• •Serum creatinine \> 220 mmol/L (2.5 mg/dL)
• •Thrombocytopenia or coagulopathy
• •Contraindication to heparin
• •Pregnancy
• •Acute illness or active systemic infection
• •Other disease process likely to limit survival to less than 12 months
• •Significant medical problem that, in the opinion of the principal investigator, would preclude enrollment into the study
• •Participation in another investigational study
• •Unwillingness to participate or lack of availability for follow-up