New Antipsychotic Strategies: Quetiapine and Risperidone vs. Fluphenazine in Treatment Resistant Schizophrenia

Inclusion Criteria

• •Males and Females, between ages 18 and 65 year sof age.
• •Females of childbearing potential must agree to use medically accepted means of contraception.
• •A diagnosis of schizophrenia according to the DSM-IV.
• •Subjects must meet retrospective criteria for treatment-resistance as defined:
• •1. Persistent positive psychotic symptoms.
• •2. Current presence of at least a moderately severe illness as rated by the total BPRS.
• •3. Persistence of illness- No evidence of good functioning in the last five years.
• •4. Drug-refectory condition defined as at least two periods of treatment in the preceding significant symptom relief.
• •Subjects must been judged competent to consent by the ESC evaluation and provide voluntary informed consent.
• •Subjects must be reliable. They must agree to cooperate with all tests and examinations required by the protocol.
• •Patients msut have a normal ophthalmoscopic exam within 6 months of a full eye exam if any lense abnormality prior to entering study.