Study of PTK787 in the Treatment of Patients With Non-Metastatic Androgen Independent Prostate Cancer

Exclusion Criteria

• •Patients may continue on a daily multivitamin, but all other herbal or alternative food supplements must be discontinued before registration.
• •Patients must be on stable doses of bisphosphonates which have been started no less than 6 weeks prior to protocol therapy.
• •Uncontrolled incurrent illness
• •Major surgery less than or equal to 4 weeks prior to randomization
• •Prior chemotherapy less than or equal to 3 weeks prior to registration
• •Prior biologic or immunotherapy less than or equal to 2 weeks prior to registration
• •Prior investigational drugs of any kind less than or equal to 4 weeks prior to registration
• •Patients who have had full field radiotherapy less than or equal to 4 weeks or limited field radiotherapy equal or less than 2 weeks prior to registration.
• •Patients must not be on nonsteroidal antiandrogen blockade.
• •Patients must have no evidence of disease on bone scan or computed tomography (CT) scan of the abdomen/pelvis.