An Open Label Dose Escalation Study Of E7080

Exclusion Criteria

• •Patients with the following characteristics will not be eligible for the study:
• •1. Brain tumors or brain or leptomeningeal metastases.
• •2. Any of the following laboratory parameters:
• •1. hemoglobin less than 9 g/dl (5.6 mmol/L)
• •2. neutrophils less than 1.5 x 10\^9/L
• •3. platelets less than 100 x 10\^9/L
• •4. serum bilirubin greater than 25 micro-mol/l (1.5 mg/dl)
• •5. other liver parameters greater than 3 x the upper limit of normal (ULN)
• •6. serum creatinine greater than 1.5 x ULN or creatinine clearance less than 60 ml/minute
• •3. Uncontrolled infections.
• •4. Clinically significant cardiac impairment or unstable ischemic heart disease including a myocardial infarction within six months of study start.
• •5. Any treatment with investigational drugs within 30 days before the start of the study.
• •6. Pregnancy or lactation (all women of childbearing potential must have a negative pregnancy test before inclusion in the study; post-menopausal women must be amenorrheic for at least 12 months). Female patients of childbearing potential must use adequate contraceptive protection, defined as two forms of contraception, one of which must be a barrier method.
• •7. Fertile males not willing to use contraception or whose female partners are not using adequate contraceptive protection.
• •8. History of alcoholism, drug addiction, or any psychiatric or psychological condition which, in the opinion of the investigator, would impair study compliance.
• •9. Legal incapacity.
• •10. Centrally located or squamous cell carcinoma of the lung.
• •11. Proteinuria greater than 1+ on bedside testing.
• •12. History of gastrointestinal malabsorption.
• •13. Surgery involving gastro- and/or intestinal anastomosis within four weeks of study start.
• •14. Patients with bleeding or thrombotic disorders.
• •15. Patients using therapeutic dosages of anticoagulants.
• •16. Poorly controlled hypertension (defined as a change in hypertensive therapy within three months of study start) or patients diagnosed with hypertension (defined as a repeat blood pressure measurement of 160/90 mmHg or higher) at screening.