Bupropion in the Treatment of Pathological Gambling

Exclusion Criteria

• •Evidence of current (past 3 months) substance misuse;
• •Had a Hamilton Depression Rating Scale (HDRS)27 score of 18 or more (or a score on item 1 of greater than 2;
• •Had a current eating disorder (except binge eating disorder);
• •Had any history of seizures, or suicidal or aggressive behavior;
• •Had a urine drug screen positive for stimulants, opiates, hallucinogens, or phencyclidine;
• •Had a current or past psychotic disorder, bipolar disorder, or significant cognitive disorder;
• •Received monoamine oxidase inhibitors within 3 weeks of randomization, long acting phenothiazine within 3 months of randomization,fluoxetine within 4 weeks of randomization, or other psychotropic drugs within 2 weeks of randomization;
• •Had prior exposure to bupropion;
• •Were engaged in individual, group, or couples psychotherapy during the 2 weeks before randomization, (except Gamblers Anonymous).