Paclitaxel and Carboplatin in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy

Exclusion Criteria

• •Patients with biochemical only progression
• •Patients who have received any prior chemotherapy for cancer of the prostate
• •Patients who received antiandrogen therapy within 4 weeks prior to the first day of treatment after cessation of flutamide or nilutamide, and or within 6 weeks prior to registration after cessation of bicalutamide
• •Patients receiving concomitant chemotherapy, biologic therapy, or radiation therapy
• •Patients who have received Strontium 89 or other radioisotope therapies
• •Patients with decreasing PSA levels following antiandrogen withdrawal
• •Patients with \> grade 1 peripheral sensory or motor neuropathy
• •Patients with known carcinomatous meningitis or brain metastases are excluded
• •Patients with past or current histories of neoplasm other than entry diagnosis except for in-situ carcinoma of any site, non-melanoma skin cancer, or other malignancy treated by surgery or radiation with a disease-free survival longer than 5 years
• •Patients who have undergone major surgery \< 3 weeks prior to registration, except for biopsy or placement of a venous access device. Patients must have fully recovered from all effects of any prior surgery
• •Patients with histories of serious cardiac disease not adequately controlled: documented myocardial infarction within the last 6 months preceding registration, congestive heart failure, unstable angina, valvular disease with documented ventricular compromise, uncontrolled hypertension, arrhythmia uncontrolled by medication, clinically significant pericardial effusion
• •Patients with active serious infections or other serious underlying medical conditions that would otherwise impair their ability to receive protocol treatments
• •Patients with dementia or significantly altered mental status that would prohibit the understanding and/or giving of informed consent
• •Patients receiving other investigational therapy
• •Use of any investigational agent within 30 days of first day of treatment and use of Ketoconazole, hydrocortisone, glucocorticoids, or megace within 30 days of first day of treatment or other concomitant medications