Combination Chemotherapy in Treating Patients With Recurrent or Refractory Leukemia or Lymphoma

You may be eligible if

• DISEASE CHARACTERISTICS:
• One of the following must be present:
• * Histologically confirmed acute myeloid leukemia or acute lymphoblastic leukemia
• * More than 5% blasts in the bone marrow or peripheral blood unrelated to recovery of normal hematopoiesis from prior chemotherapy
• * Failed at least 1 attempt at induction chemotherapy
• * Diagnosis of non-Hodgkin's lymphoma or Hodgkin's lymphoma
• * Refractory or relapsed after at least 1 regimen of standard chemotherapy
• * Diagnosis of chronic myelogenous leukemia in accelerated phase or blast crisis
• * Received at least 1 myelotoxic chemotherapy regimen
• Active CNS involvement allowed
• PATIENT CHARACTERISTICS:
• Age
• 55 and under
• Performance status
• ECOG 0-2
• Life expectancy
• At least 5 weeks
• Hematopoietic
• Lymphoma patients:
• * WBC at least 2,000/mm\^3\*
• * Platelet count at least 20,000/mm\^3\* NOTE: \*Unless due to bone marrow involvement or disease process
• Hepatic
• Bilirubin no greater than 3 times normal\*
• AST/ALT no greater than 3 times normal\*
• Alkaline phosphatase no greater than 3 times normal\*
• No severe liver failure NOTE: \*Unless related to leukemia
• Renal
• Creatinine clearance greater than 50 mL/min
• No severe renal failure
• Cardiovascular
• LVEF at least 45% by MUGA
• Pulmonary
• DLCO at least 60% of predicted
• Other
• HIV negative
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• No psychiatric illness that would preclude informed consent
• No medical illness or other condition that would preclude study participation
• PRIOR CONCURRENT THERAPY:
• Biologic therapy
• Not specified
• Chemotherapy
• See Disease Characteristics
• At least 24 hours since prior hydroxyurea
• At least 1 week since other prior chemotherapy
• Endocrine therapy
• Not specified
• Radiotherapy
• Not specified
• Surgery
• Not specified
• Other
• Recovered from prior therapy